About: GD2 Lactone/GD3 Lactone-KLH Conjugate Bivalent Vaccine     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • GD2 Lactone/GD3 Lactone-KLH Conjugate Bivalent Vaccine
rdfs:subClassOf
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • GD2 Lactone/GD3 Lactone-KLH Conjugate Bivalent Vaccine
NCI_META_CUI
  • CL383507
PDQ_Open_Trial_Search_ID
  • 588002
PDQ_Closed_Trial_Search_ID
  • 588002
Legacy_Concept_Name
  • GD2_Lactone_GD3_Lactone-KLH_Conjugate_Bivalent_Vaccine
FULL_SYN
  • GD2 Lactone/GD3 Lactone-KLH Conjugate Bivalent VaccinePTNCI
DEFINITION
  • A cancer vaccine, containing epitopes of the gangliosides GD2 and GD3 conjugated with the immunostimulant keyhole limpet hemocyanin (KLH), with potential antineoplastic activity. Vaccination with GD2 lactone/GD3 lactone-KLH conjugate bivalent vaccine may elicit antibodies against tumor cells expressing either epitope, resulting in complement-mediated cytotoxicity (CMC) and antibody-dependent cell-mediated cytotoxicity (ADCC). Located primarily in the nervous system, gangliosides, such as GD2 and GD3, are cell membrane components involved in cellular recognition and cell-cell communication.NCI
code
  • C74035
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