About: Anti-CD37 Single-Chain Polypeptide TRU-016     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Anti-CD37 Single-Chain Polypeptide TRU-016
rdfs:subClassOf
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Anti-CD37 Single-Chain Polypeptide TRU-016
UMLS_CUI
  • C2346800
PDQ_Open_Trial_Search_ID
  • 589521
PDQ_Closed_Trial_Search_ID
  • 589521
Legacy_Concept_Name
  • Anti-CD37_Single-Chain_Polypeptide_TRU-016
FULL_SYN
  • TRU-016CNNCI
  • Anti-CD37 Single-Chain Polypeptide TRU-016PTNCI
DEFINITION
  • A recombinant single-chain polypeptide engineered to exhibit the full binding and activity of an anti-CD37 monoclonal antibody with potential immunostimulatory and antineoplastic activities. Anti-CD37 single-chain polypeptide TRU-016 binds to CD37 on B-cells, which may result in antibody-dependent cell-mediated cytotoxicity (ADCC) and apoptosis. CD37 is a transmembrane glycoprotein expressed at high-levels on B cells and to a lesser extent on T cells and myeloid cells. This agent may have a longer half-life in vivo than conventional monoclonal antibodies.NCI
code
  • C74006
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