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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Phenobarbital
rdfs:subClassOf
Has_Salt_Form
Concept_In_Subset
Semantic_Type
  • Organic Chemical
  • Pharmacologic Substance
Preferred_Name
  • Phenobarbital
NSC_Code
  • 128143
  • 9848
UMLS_CUI
  • C0031412
CAS_Registry
  • 50-06-6
Accepted_Therapeutic_Use_For
  • Epilepsy
FDA_UNII_Code
  • YQE403BP4D
Contributing_Source
  • FDA
ALT_DEFINITION
  • A drug that is used to treat seizures and as a sedative. It is being studied in the treatment of diarrhea and for its ability to increase the antitumor effect of other therapies. It belongs to the family of drugs called barbiturates.NCI-GLOSS
PDQ_Open_Trial_Search_ID
  • 42405
PDQ_Closed_Trial_Search_ID
  • 42405
Chemical_Formula
  • C12H12N2O3
Legacy_Concept_Name
  • Phenobarbital
CHEBI_ID
  • CHEBI:8069
FULL_SYN
  • PHENOBARBITALPTFDAYQE403BP4D
  • PhenobarbitalPTNCI
  • phenobarbitalPTNCI-GLOSSCDR0000045470
  • PHENOABNCI
  • 5-Ethyl-5-phenyl-2,4,6(1H,3H,5H)-pyrimidinetrioneSNNCI
  • PhenobarbitalPTDCP00018
DEFINITION
  • A long-acting barbituric acid derivative with antipsychotic property. Phenobarbital binds to and activates the gamma-aminobutyric acid (GABA)-A receptor, thereby mimicking the inhibitory actions of GABA in the brain. The activation effects of the phenobarbital-receptor-ionophore complex include increased frequency of chloride channel openings, membrane hyperpolarization and ultimately synaptic inhibition and decreased neuronal excitability. In addition, this agent inhibits glutamate induced depolarization.NCI
code
  • C739
sameAs
http://linked.open...y/mesh/hasConcept
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