About: Fosaprepitant Dimeglumine     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Fosaprepitant Dimeglumine
rdfs:subClassOf
Concept_In_Subset
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Fosaprepitant Dimeglumine
UMLS_CUI
  • C2315887
CAS_Registry
  • 265121-04-8
FDA_UNII_Code
  • D35FM8T64X
Contributing_Source
  • FDA
ALT_DEFINITION
  • A drug used together with other drugs to prevent and control nausea and vomiting caused by cancer treatment. It is given in a vein. It is a type of antiemetic and a type of substance P/neurokinin 1 receptor antagonist.NCI-GLOSS
PDQ_Open_Trial_Search_ID
  • 642614
PDQ_Closed_Trial_Search_ID
  • 642614
Chemical_Formula
  • C23H22F7N4O6P.2C7H17NO5
Legacy_Concept_Name
  • Fosaprepitant_Dimeglumine
CHEBI_ID
  • CHEBI:64311
FULL_SYN
  • fosaprepitant dimegluminePTNCI-GLOSSCDR0000648590
  • Emend for InjectionPTNCI-GLOSSCDR0000648591
  • Fosaprepitant DimegluminePTNCI
  • FOSAPREPITANT DIMEGLUMINEPTFDAD35FM8T64X
DEFINITION
  • The dimeglumine salt form of fosaprepitant, the water-soluble, N-phosphorylated prodrug of aprepitant, with antiemetic activity. Upon intravenous administration and rapid conversion to aprepitant, this agent binds selectively to the human substance P/neurokinin 1 (NK1) receptors in the central nervous system (CNS). This inhibits receptor binding of the endogenous substance P and prevents substance P-induced emesis.NCI
code
  • C72788
sameAs
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