About: Delapril Hydrochloride     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Delapril Hydrochloride
rdfs:subClassOf
Has_Free_Acid_Or_Base_Form
Concept_In_Subset
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Delapril Hydrochloride
UMLS_CUI
  • C2348090
CAS_Registry
  • 83435-67-0
FDA_UNII_Code
  • 2SMM3M5ZMH
Contributing_Source
  • FDA
Chemical_Formula
  • C26H32N2O5.HCl
Legacy_Concept_Name
  • Delapril_Hydrochloride
FULL_SYN
  • Delapril HydrochloridePTNCI
  • DELAPRIL HYDROCHLORIDEPTFDA2SMM3M5ZMH
DEFINITION
  • The hydrochloride salt of delapril, a lipophilic, non-sulfhydryl angiotensin-converting enzyme (ACE) inhibitor with antihypertensive activity. As a prodrug, delapril is converted to two active metabolites, delapril diacid and 5-hydroxy delapril diacid, which competitively bind to and inhibit ACE, thereby blocking the conversion of angiotensin I to angiotensin II. This prevents the potent vasoconstrictive actions of angiotensin II and results in vasodilation. Delapril also decreases angiotensin II-induced aldosterone secretion by the adrenal cortex, which leads to an increase in sodium excretion and subsequently increases water outflow.NCI
code
  • C72734
is Has_Salt_Form of
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