About: Ciglitazone     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Ciglitazone
rdfs:subClassOf
Concept_In_Subset
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Ciglitazone
UMLS_CUI
  • C0055721
CAS_Registry
  • 74772-77-3
FDA_UNII_Code
  • U8QXS1WU8G
Contributing_Source
  • FDA
Chemical_Formula
  • C18H23NO3S
Legacy_Concept_Name
  • Ciglitazone
CHEBI_ID
  • CHEBI:64227
FULL_SYN
  • CiglitazonePTNCI
  • CIGLITAZONEPTFDAU8QXS1WU8G
DEFINITION
  • An agent belonging to the glitazone (thiazolidinedione) class of antidiabetic agents with antihyperglycemic activity. Ciglitazone also exerts anti-inflammatory activity through the modulation of nuclear factor-kappaB-mediated pathways. In addition, this agent inhibits angiogenesis by reducing vascular endothelial growth factor (VEGF) production and inhibits growth of melanoma cells by inhibiting the expression of (C-X-C motif) ligand 1 (CXCL1). This agent is the prototypical compound for the thiazolidinedione class, and has never been marketed.NCI
code
  • C72726
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