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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Protionamide
rdfs:subClassOf
Concept_In_Subset
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Protionamide
UMLS_CUI
  • C0033705
CAS_Registry
  • 14222-60-7
FDA_UNII_Code
  • 76YOO33643
Contributing_Source
  • FDA
Chemical_Formula
  • C9H12N2S
Legacy_Concept_Name
  • Protionamide
FULL_SYN
  • PROTIONAMIDEPTFDA76YOO33643
  • 2-Propylpyridine-4-carbothioamideSNNCI
  • ProtionamidePTNCI
  • ProthionamideSYNCI
DEFINITION
  • A thioamide derivative with antitubercular activity. Protionamide forms a covalent adduct with bacterial nicotinamide adenine dinucleotide (NAD), PTH-NAD, which competitively inhibits 2-trans-enoyl-ACP reductase (inhA), an enzyme essential for mycolic acid synthesis. This results in increased cell wall permeability and decreased resistance against cell injury eventually leading to cell lysis. Mycolic acids, long-chain fatty acids, are essential mycobacterial cell wall components and play a key role in resistance to cell injury and mycobacterial virulence.NCI
code
  • C72605
sameAs
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