About: Nucleotide Analogue GS 9219     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Nucleotide Analogue GS 9219
rdfs:subClassOf
Semantic_Type
  • Pharmacologic Substance
  • Nucleic Acid, Nucleoside, or Nucleotide
Preferred_Name
  • Nucleotide Analogue GS 9219
NSC_Code
  • 287459
NCI_META_CUI
  • CL376149
PDQ_Open_Trial_Search_ID
  • 560932
PDQ_Closed_Trial_Search_ID
  • 560932
Legacy_Concept_Name
  • Nucleotide_Analogue_GS_9219
FULL_SYN
  • 9-(2-phosphonylmethoxyethyl)guanine nucleotide analogue prodrug GS 9219SYNCI
  • Nucleotide Analogue GS 9219PTNCI
  • GS9219CNNCI
DEFINITION
  • A prodrug of the acyclic nucleoside phosphonate analogue 9-(2-phosphonylmethoxyethyl)guanine (PMEG) with potential antineoplastic activity. Formulated to selectively accumulate in lymphocytes, nucleotide analogue GS 9219 is converted to its active metabolite, PMEG diphosphate (PMEGpp), via enzymatic hydrolysis, deamination, and phosphorylation; subsequently, PMEGpp is incorporated into nascent DNA chains by DNA polymerases, which may result in the termination of DNA synthesis, S-phase cell cycle arrest, and the induction of apoptosis in susceptible lymphoma cell populations.NCI
code
  • C71742
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