About: Survivin Sur1M2 Peptide Vaccine     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Survivin Sur1M2 Peptide Vaccine
rdfs:subClassOf
Semantic_Type
  • Pharmacologic Substance
  • Immunologic Factor
Preferred_Name
  • Survivin Sur1M2 Peptide Vaccine
NCI_META_CUI
  • CL376129
PDQ_Open_Trial_Search_ID
  • 559164
PDQ_Closed_Trial_Search_ID
  • 559164
Legacy_Concept_Name
  • Survivin_Sur1M2_Peptide_Vaccine
FULL_SYN
  • Survivin Sur1M2 Peptide VaccinePTNCI
DEFINITION
  • A modified recombinant nonapeptide (LMLGEFLKL) derived from the anti-apoptosis protein survivin with potential immunopotentiating and antineoplastic activities. Upon administration, survivin Sur1M2 peptide vaccine may elicit humoral and cellular immune responses against survivin-expressing cancers, resulting in decreased tumor cell proliferation and tumor cell death. The survivin protein inhibits caspase activation and apoptosis; it is undetectable in normal adult tissues but is expressed by several human cancers including lung, colon, breast, pancreas, and prostate cancer as well as hematopoietic malignancies and skin cancers.NCI
code
  • C71741
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