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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Apomab
rdfs:subClassOf
Has_Target
Semantic_Type
  • Amino Acid, Peptide, or Protein
  • Immunologic Factor
Preferred_Name
  • Apomab
UMLS_CUI
  • C2346838
PDQ_Open_Trial_Search_ID
  • 555507
PDQ_Closed_Trial_Search_ID
  • 555507
Legacy_Concept_Name
  • Apomab
FULL_SYN
  • ApomabPTNCI
DEFINITION
  • A fully human monoclonal antibody directed against human death receptor 5 (DR5; TRAIL-R2; TNFRSF10B) with potential pro-apoptotic and antineoplastic activities. Mimicking the natural ligand TRAIL (tumor necrosis factor-related apoptosis inducing ligand), apomab binds to DR5, which may directly activate the extrinsic apoptosis pathway and indirectly induce the intrinsic apoptosis pathway in tumor cells. DR5 is a cell surface receptor of the TNF-receptor superfamily and is expressed in a broad range of cancers.NCI
code
  • C71693
http://linked.open...y/mesh/hasConcept
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