About: Fludrocortisone     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Fludrocortisone
rdfs:subClassOf
Concept_In_Subset
Semantic_Type
  • Pharmacologic Substance
  • Steroid
Preferred_Name
  • Fludrocortisone
NSC_Code
  • 11318
UMLS_CUI
  • C0016280
CAS_Registry
  • 127-31-1
FDA_UNII_Code
  • U0476M545B
Contributing_Source
  • FDA
ALT_DEFINITION
  • A synthetic corticosteroid. It is used to replace steroid hormones normally produced by the adrenal gland.NCI-GLOSS
Chemical_Formula
  • C21H29FO5
Legacy_Concept_Name
  • Fludrocortisone_Base
CHEBI_ID
  • CHEBI:50885
FULL_SYN
  • FLUDROCORTISONEPTFDAU0476M545B
  • FludrocortisonePTNCI
  • FludrocortisoneSYDTPNSC0011318
  • FlorinefSYDTPNSC0011318
  • fludrocortisonePTNCI-GLOSSCDR0000045199
DEFINITION
  • A synthetic corticosteroid with antiinflammatory and antiallergic properties. Fludrocortisone is a mineralocorticoid receptor and glucocorticoid receptor agonist that binds to cytoplasmic receptors, translocates to the nucleus and subsequently initiates the transcription of glucocorticoid-responsive genes such as lipocortins to inhibit phospholipase A2. This prevents the release of arachidonic acid, a precursor to prostaglandins and leukotrienes, both important mediators in the pro-inflammatory response mechanism. In addition, this agent exerts its mineralocorticoid effect on the distal tubules and collecting ducts of the kidney by inducing permease, an enzyme that regulates Na+ permeability in cells, thereby enhancing Na+ reabsorption and water retention as well as increasing K+, H+ excretion.NCI
code
  • C71629
sameAs
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