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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Biricodar
rdfs:subClassOf
Has_Salt_Form
Concept_In_Subset
Semantic_Type
  • Organic Chemical
  • Pharmacologic Substance
Preferred_Name
  • Biricodar
UMLS_CUI
  • C0754576
CAS_Registry
  • 159997-94-1
FDA_UNII_Code
  • 3KG76X4KJK
Contributing_Source
  • FDA
Chemical_Formula
  • C34H41N3O7
Legacy_Concept_Name
  • Biricodar
FULL_SYN
  • VX-710CNNCI
  • BIRICODARPTFDA3KG76X4KJK
  • BiricodarPTNCI
DEFINITION
  • A pipecolinate derivative. Functioning as a modulator of P-glycoprotein (P-gp) and multidrug resistance protein (MRP-1), biricodar restores drug sensitivity to cells expressing P-glycoprotein and MRP1, the cellular efflux pumps that are the major causes in tumor cell resistance to chemotherapeutic agents. This agent binds directly to Pgp and MRP-1 and inhibits efflux pump activity, resulting in increased intracellular accumulation and retention of cytotoxic agents.NCI
code
  • C71621
http://linked.open...y/mesh/hasConcept
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