About: Bromovinyl-Deoxyuridine     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : owl:DeprecatedClass, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Bromovinyl-Deoxyuridine
rdfs:subClassOf
Semantic_Type
  • Chemical Viewed Functionally
Preferred_Name
  • Bromovinyl-Deoxyuridine
OLD_PARENT
  • Enzyme_Inhibitor
NCI_META_CUI
  • CL378100
Concept_Status
  • Retired_Concept
PDQ_Open_Trial_Search_ID
  • 577369
PDQ_Closed_Trial_Search_ID
  • 577369
Legacy_Concept_Name
  • Bromovinyl-Deoxyuridine
FULL_SYN
  • Bromovinyl-DeoxyuridinePTNCI
DEFINITION
  • A uridine derivative and nucleoside analog with pro-apoptotic and chemosensitizing properties. In vitro, bromovinyl-deoxyuridine (BVDU) has been shown to downregulate the multifunctional DNA repair enzyme APEX nuclease 1, resulting in the inhibition of DNA repair and the induction of apoptosis. In addition, this agent may inhibit the expression of STAT3 (signal transducer and activator of transcription 3), which may result in the downregulation of vascular endothelial growth factor (VEGF). BVDU has also been found to inhibit the upregulation of chemoresistance genes (Mdr1 and DHFR) during chemotherapy. Overall, the gene expression changes associated with BVDU treatment result in the decrease or prevention of chemoresistance. In addition, this agent has been shown to enhance the cytolytic activity of NK-92 natural killer cells towards a pancreatic cancer cell line in vitro.NCI
DesignNote
  • Mon Feb 20 13:22:43 EST 2012 - See 'Brivudine'
code
  • C71528
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