About: Autologous Follicular Lymphoma-Derived Idiotype Vaccine     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Autologous Follicular Lymphoma-Derived Idiotype Vaccine
rdfs:subClassOf
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Autologous Follicular Lymphoma-Derived Idiotype Vaccine
UMLS_CUI
  • C2346884
PDQ_Open_Trial_Search_ID
  • 572211
PDQ_Closed_Trial_Search_ID
  • 572211
Legacy_Concept_Name
  • Autologous_Follicular_Lymphoma-Derived_Idiotype_Vaccine
FULL_SYN
  • Autologous Follicular Lymphoma-Derived Idiotype VaccinePTNCI
DEFINITION
  • A patient-specific cancer vaccine directed against the soluble protein idiotype of an individual follicular lymphoma with potential antineoplastic activity. A patient-specific follicular lymphoma-derived anti-idiotype vaccine may be composed of a patient-specific, synthetic idiotype-related peptide (such as one corresponding to a hypervariable region of an IgG heavy chain) conjugated to the immunostimulant carrier protein keyhole limpet hemocyanin (KLH). Upon administration, this vaccine may induce an idiotype-specific cytotoxic T-lymphocyte (CTL) response against follicular lymphoma cells expressing the idiotype, resulting in tumor cell lysis.NCI
code
  • C71036
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