About: Mycobacterium w     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Mycobacterium w
rdfs:subClassOf
Semantic_Type
  • Immunologic Factor
  • Bacterium
Preferred_Name
  • Mycobacterium w
NCI_META_CUI
  • CL375836
In_Clinical_Trial_For
  • Hormone Refractory Prostate cancer
PDQ_Open_Trial_Search_ID
  • 571076
PDQ_Closed_Trial_Search_ID
  • 571076
Legacy_Concept_Name
  • Mycobacterium_w
FULL_SYN
  • Mycobacterium wPTNCI
  • ImmuvacBRNCI
DEFINITION
  • An attenuated strain of Mycobacterium w, a non-pathogenic, rapidly growing, atypical mycobacterium, with non-specific immunopotentiating properties. In addition to sharing a number of common B and T cell determinants with Mycobacterium leprae and Mycobacterium tuberculosis, Mycobacterium w (Mw) also shares an immunogenic determinant with prostate specific antigen (PSA). In vitro and in vivo studies have shown that heat-killed Mw can induce significant T-cell responses. This agent may induce host T-cell responses against tumor cells expressing PSA. PSA is a glycoprotein secreted by prostatic epithelial and ductal cells and may be overexpressed in prostate cancer cells.NCI
code
  • C70969
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