About: Masoprocol     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Masoprocol
rdfs:subClassOf
Concept_In_Subset
Semantic_Type
  • Organic Chemical
  • Pharmacologic Substance
Preferred_Name
  • Masoprocol
PubMedID_Primary_Reference
  • 8450672
NSC_Code
  • 4291
UMLS_CUI
  • C0733397
CAS_Registry
  • 27686-84-6
FDA_UNII_Code
  • 7BO8G1BYQU
Contributing_Source
  • FDA
ALT_DEFINITION
  • A drug put on the skin to treat growths caused by sun exposure. A form of Masoprocol that is taken by mouth is being studied in the treatment of prostate cancer. Masoprocol is an antioxidant, and it may block certain enzymes needed for tumor growth.NCI-GLOSS
PDQ_Open_Trial_Search_ID
  • 479648
PDQ_Closed_Trial_Search_ID
  • 479648
Chemical_Formula
  • C18H22O4
Legacy_Concept_Name
  • Nordihydroguaiaretic_Acid
FULL_SYN
  • NDGASYDTPNSC0004291
  • 4,4'-(2,3-Dimethyl-1,4-butanediyl)bis[1,2-benzenediol]SNNCI
  • masoprocolPTNCI-GLOSSCDR0000523329
  • NDGAPTNCI-GLOSSCDR0000523328
  • Nordihydroguaiaretic AcidPTDCP00617
  • Nordihydroguaiaretic AcidSYNCI
  • NDGAABNCI
  • NDHGAABNCI
  • ActinexPTNCI-GLOSSCDR0000523330
  • ActinexBRNCI
  • MASOPROCOLPTFDA7BO8G1BYQU
  • Nordihydroguaiaretic acidSYDTPNSC0004291
  • MasoprocolPTNCI
DEFINITION
  • A naturally occurring antioxidant dicatechol originally derived from the creosote bush Larrea divaricatta with antipromoter, anti-inflammatory, and antineoplastic activities. Masoprocol directly inhibits activation of two receptor tyrosine kinases (RTKs), the insulin-like growth factor receptor (IGF-1R) and the c-erbB2/HER2/neu receptor, resulting in decreased proliferation of susceptible tumor cell populations. This agent may induce apoptosis in susceptible tumor cell populations as a result of disruption of the actin cytoskeleton in association with the activation of stress activated protein kinases (SAPKs). In addition, masoprocol inhibits arachidonic acid 5-lipoxygenase (5LOX), resulting in diminished synthesis of inflammatory mediators such as prostaglandins and leukotrienes. It may prevent leukocyte infiltration into tissues and the release of reactive oxygen species.NCI
code
  • C701
sameAs
http://linked.open...y/mesh/hasConcept
is sameAs of
Faceted Search & Find service v1.16.118 as of Jun 21 2024


Alternative Linked Data Documents: ODE     Content Formats:   [cxml] [csv]     RDF   [text] [turtle] [ld+json] [rdf+json] [rdf+xml]     ODATA   [atom+xml] [odata+json]     Microdata   [microdata+json] [html]    About   
This material is Open Knowledge   W3C Semantic Web Technology [RDF Data] Valid XHTML + RDFa
OpenLink Virtuoso version 07.20.3240 as of Jun 21 2024, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (126 GB total memory, 48 GB memory in use)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software