About: D-methionine Formulation MRX-1024     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • D-methionine Formulation MRX-1024
rdfs:subClassOf
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • D-methionine Formulation MRX-1024
NCI_META_CUI
  • CL371849
PDQ_Open_Trial_Search_ID
  • 540244
PDQ_Closed_Trial_Search_ID
  • 540244
Legacy_Concept_Name
  • D-methionine_Formulation_MRX-1024
FULL_SYN
  • D-methionine Formulation MRX-1024PTNCI
  • MRX-1024CNNCI
DEFINITION
  • A proprietary oral formulation of D-methionine with antioxidant and antimucositis activities. D-methionine formulation MRX-1024 may selectively protect the oral mucosa from the toxic effects of chemotherapy and radiation therapy without compromising antitumor activity. D-methionine may be converted into the L- isomer in vivo, particularly in instances of L-methionine deprivation; both isomers have antioxidant activity which may be due, in part, to their sulfur moieties and chelating properties. L-methionine, an essential amino acid, also may help to maintain the ratio of reduced glutathione to oxidized glutathione in cells undergoing oxidative stress and may provide a source of L-cysteine for glutathione synthesis.NCI
code
  • C69140
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