About: Apoptosis Inducer BZL101     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Apoptosis Inducer BZL101
rdfs:subClassOf
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Apoptosis Inducer BZL101
UMLS_CUI
  • C1999759
PDQ_Open_Trial_Search_ID
  • 543519
PDQ_Closed_Trial_Search_ID
  • 543519
Legacy_Concept_Name
  • Apoptosis_Inducer_BZL101
FULL_SYN
  • Apoptosis Inducer BZL101PTNCI
  • BZL101CNNCI
DEFINITION
  • An orally active aqueous extract derived from the plant Scutellaria barbata with potential antineoplastic activity. Sparing normal cells, apoptosis inducer BZL101 specifically facilitates translocation of the protein apoptosis-inducing factor (AIF) from the mitochondrial membrane into the nucleus in tumor cells, thereby causing tumor cell-specific chromatin condensation and DNA degradation followed by the induction of caspase-independent apoptosis. AIF is both a mitochondrial intermembrane flavoprotein with oxidoreductase activity and a caspase-independent death effector that, similar to cytochrome c, is released from mitochondria early in the apoptotic process.NCI
code
  • C69134
http://linked.open...y/mesh/hasConcept
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