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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Rindopepimut
rdfs:subClassOf
Semantic_Type
  • Pharmacologic Substance
  • Immunologic Factor
Preferred_Name
  • Rindopepimut
UMLS_CUI
  • C2346809
CAS_Registry
  • 946156-74-7
Accepted_Therapeutic_Use_For
  • Immunotherapy for glioblastoma multiforme
PDQ_Open_Trial_Search_ID
  • 546970
PDQ_Closed_Trial_Search_ID
  • 546970
Legacy_Concept_Name
  • Anti-EGFRvIII_Vaccine_CDX-110
FULL_SYN
  • RindopepimutPTNCI
  • Anti-EGFRvIII Vaccine CDX-110SYNCI
  • CDX-110CNNCI
  • L-Cysteine, L-leucyl-L-alpha-glutamyl-L-alpha-glutamyl-L-lysyl-L-lysylglycyl-L-asparaginyl-L-tyrosyl-L-valyl-L-valyl-L-threonyl-L-alpha-aspartyl-L-histidyl-S-(1-((4-carboxycyclohexyl)methyl)-2,5-dioxo-3-pyrrolidinyl)-, complex with hemocyanin (Megathura crenulata)SNNCI
  • PF-04948568CNNCI
DEFINITION
  • A cancer vaccine consisting of a human epidermal growth factor receptor variant III (EGFRvIIi)-specific peptide conjugated to the non-specific immunomodulator keyhole limpet hemocyanin (KLH) with potential antineoplastic activity. Vaccination with anti-EGFRvIII vaccine CDX-110 may elicit a cytotoxic T-lymphocyte (CTL) immune response against tumor cells expressing EGFRvIII. EGFRvIII, a functional variant of EGFR that is not expressed in normal tissues, was originally discovered in glioblastoma multiforme (GBM) and has also been found in various other cancers such as breast, ovarian, metastatic prostate, colorectal, and head and neck cancers. EGFRvIII contains an 83 amino acid deletion in its extracellular domain and has been shown to transform NIH/3T3 mouse embryonic fibroblast cells in vitro.NCI
code
  • C69076
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