About: Niacin

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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	Class
rdfs:label	Niacin
rdfs:subClassOf	B Vitamin
Concept_In_Subset	FDA Established Names and Unique Ingredient Identifier Codes Terminology
Semantic_Type	Organic Chemical Vitamin
Preferred_Name	Niacin
NSC_Code	169454
UMLS_CUI	C0027996
CAS_Registry	59-67-6
FDA_UNII_Code	2679MF687A
Contributing_Source	CRCH FDA
ALT_DEFINITION	A nutrient in the vitamin B complex that the body needs in small amounts to function and stay healthy. Niacin helps some enzymes work properly and helps skin, nerves, and the digestive tract stay healthy. Niacin is found in many plant and animal products. It is water-soluble (can dissolve in water) and must be taken in every day. Not enough niacin can cause a disease called pellagra (a condition marked by skin, nerve, and digestive disorders). A form of niacin is being studied in the prevention of skin and other types of cancer. Niacin may help to lower blood cholesterol.NCI-GLOSS Water-soluble vitamin that is a cosubstrate or coenzyme with numerous dehydrogenases for the transfer of the hydride ion. (DRI)CRCH A water-soluble vitamin of the B complex occurring in various animal and plant tissues. It is required by the body for the formation of coenzymes NAD and NADP. It has PELLAGRA-curative, vasodilating, and antilipemic properties.MSH2002_06_01
PDQ_Open_Trial_Search_ID	38351
PDQ_Closed_Trial_Search_ID	38351
Chemical_Formula	C6H5NO2
US_Recommended_Intake	Y
Tolerable_Level	Y
INFOODS	NIA
USDA_ID	406
Unit	mg
Nutrient	Y
Micronutrient	Y
Legacy_Concept_Name	Niacin
CHEBI_ID	CHEBI:15940
FULL_SYN	vitamin B3PTNCI-GLOSSCDR0000629155 Vitamin B-3SYCRCH NIACINPTFDA2679MF687A NicotinamideSYCRCH NiacinSYDTPNSC0169454 Nicotinic AcidSYNCI 3-Pyridinecarboxylic AcidSNNCI Nicotinic acidSYDTPNSC0015010 niacinPTNCI-GLOSSCDR0000556407 nicotinic acidPTNCI-GLOSSCDR0000629154 NiacinPTNCI Nicotinic AcidPTDCP06743 NiacinPTCRCH Vitamin B3SYDTPNSC0027452 Nicotinic Acid AmideSYCRCH Vitamin B3SYNCI
DEFINITION	A water-soluble vitamin belonging to the vitamin B family, which occurs in many animal and plant tissues, with antihyperlipidemic activity. Niacin is converted to its active form niacinamide, which is a component of the coenzymes nicotinamide adenine dinucleotide (NAD) and its phosphate form, NADP. These coenzymes play an important role in tissue respiration and in glycogen, lipid, amino acid, protein, and purine metabolism. Although the exact mechanism of action by which niacin lowers cholesterol is not fully understood, it may act by inhibiting the synthesis of very low density lipoproteins (VLDL), inhibiting the release of free fatty acids from adipose tissue, increasing lipoprotein lipase activity, and reducing the hepatic synthesis of VLDL-C and LDL-C.NCI
code	C689
sameAs	NIACIN NIACIN
http://linked.open...y/mesh/hasConcept	http://linked.opendata.cz/resource/mesh/concept/M0014807
is sameAs of	NIACIN NIACIN NIACIN NIACIN

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