About: Autologous Ad-CD154-Transduced CLL B Cells     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Autologous Ad-CD154-Transduced CLL B Cells
rdfs:subClassOf
Semantic_Type
  • Immunologic Factor
Preferred_Name
  • Autologous Ad-CD154-Transduced CLL B Cells
NCI_META_CUI
  • CL374420
PDQ_Open_Trial_Search_ID
  • 552982
PDQ_Closed_Trial_Search_ID
  • 552982
Legacy_Concept_Name
  • Autologous_Ad-CD154-Transduced_CLL_B_Cells
FULL_SYN
  • L-VaxBRNCI
  • Autologous Ad-CD154-Transduced CLL B CellsPTNCI
DEFINITION
  • An autologous tumor cell vaccine containing chronic lymphocytic leukemia (CLL) B cells transduced with an adenoviral vector carrying chimeric CD154 (ad-CD154) with potential antineoplastic activity. Administration of autologous ad-CD154 transduced CLL B cells may result in increases in the numbers of leukemia-specific CD4+ T cells and high serum-levels of IL-12 and IFN-gamma. Due to ligation of CD154 to CD40 on CLL cells, this agent may induce CLL cells to express the proapoptotic molecule BID and death receptors CD95 (Fas) and DR5, rendering CLL B cells first resistant and then sensitive to Fas-mediated apoptosis. In addition, autologous ad-CD154 transduced CLL B cells may induce MHC class I-dependent cytotoxic T lymphocyte (CTL) responses against autologous leukemia cells. CD154 is a type II membrane glycoprotein and ligand for CD40; both molecules are important in cognate co-stimulatory cell-cell interactions.NCI
code
  • C68842
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