About: Naltrexone Hydrochloride     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Naltrexone Hydrochloride
rdfs:subClassOf
Has_Free_Acid_Or_Base_Form
Concept_In_Subset
Semantic_Type
  • Organic Chemical
  • Pharmacologic Substance
Preferred_Name
  • Naltrexone Hydrochloride
UMLS_CUI
  • C0355800
CAS_Registry
  • 16676-29-2
FDA_UNII_Code
  • Z6375YW9SF
Contributing_Source
  • FDA
ALT_DEFINITION
  • A drug that blocks the action of opiates (drugs used to treat pain). It may be used in the treatment of intravenous opiate addiction or alcohol dependence. Naltrexone hydrochloride is also being studied in the treatment of breast cancer. It may block the effects of the hormone estrogen, which causes some breast cancer cells to grow, or block the blood flow to tumors. It is a type of opiate antagonist.NCI-GLOSS
  • Derivative of noroxymorphone that is the N-cyclopropylmethyl congener of NALOXONE. It is a narcotic antagonist that is effective orally, longer lasting and more potent than naloxone, and has been proposed for the treatment of heroin addiction. The FDA has approved naltrexone for the treatment of alcohol dependence.MSH2002_06_01
PDQ_Open_Trial_Search_ID
  • 40818
PDQ_Closed_Trial_Search_ID
  • 40818
Chemical_Formula
  • C20H23NO4.HCl
Legacy_Concept_Name
  • Naltrexone
FULL_SYN
  • naltrexone hydrochloridePTNCI-GLOSSCDR0000549273
  • Naltrexone HydrochloridePTNCI
  • ReViaPTNCI-GLOSSCDR0000549316
  • NALTREXONE HYDROCHLORIDEPTFDAZ6375YW9SF
  • ReviaBRNCI
  • DepadeBRNCI
  • Naltrexone.HClPTDCP20102
  • (5alpha)-17-(Cyclopropylmethyl)-4,5-epoxy-3,14-dihydroxymorphinan-6-one HydrochlorideSNNCI
DEFINITION
  • The hydrochloride salt of naltrexone, a noroxymorphone derivative with competitive opioid antagonistic activity. Naltrexone and its metabolite 6-beta-naltrexol reverse the effects of opioids by binding to various opioid receptors in the central nervous system CNS), including the mu-, kappa- and gamma-opioid receptors; opioid effects of analgesia, euphoria, sedation, respiratory depression, miosis, bradycardia, and physical dependence are inhibited. Naltrexone is longer-acting and more potent compared to naloxone.NCI
code
  • C679
sameAs
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