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AttributesValues
rdf:type
rdfs:label
  • Mitotic Enzyme Modulator
rdfs:subClassOf
Semantic_Type
  • Chemical Viewed Functionally
Preferred_Name
  • Mitotic Enzyme Modulator
UMLS_CUI
  • C1881870
Legacy_Concept_Name
  • Mitotic_Enzyme_Modulator
FULL_SYN
  • Mitotic Enzyme ModulatorPTNCI
DEFINITION
  • A class of compounds that modulate the activity of mitotic enzymes. Mitotic enzymes regulate various mitotic events including centrosome separation, mitotic spindle assembly, chromosome alignment, phosphorylation of tubulin and cell-cycle regulators, and interaction with mitotic kinesins; other roles include facilitating the progression through and the exit from mitosis as well as regulating cytokinesis. Agents that modulate the activity of mitotic enzymes, specifically those that inhibit cytokinesis, may produce an anti-mitotic effect resulting from the aberrant formation of abnormal or polyploid cells and their subsequent exit from mitosis, which triggers apoptosis-an effect unrelated to the classical mitotic arrest described with other anti-mitotic compounds.NCI
code
  • C67443
is rdfs:subClassOf of
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