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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Daporinad
rdfs:subClassOf
Concept_In_Subset
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Daporinad
UMLS_CUI
  • C1879518
CAS_Registry
  • 658084-64-1
FDA_UNII_Code
  • V71TF6V9M7
Contributing_Source
  • FDA
PDQ_Open_Trial_Search_ID
  • 537396
PDQ_Closed_Trial_Search_ID
  • 537396
Chemical_Formula
  • C24H29N3O2
Legacy_Concept_Name
  • APO866
FULL_SYN
  • (2E)-N-(4-(1-Benzoylpiperidin-4-yl)butyl)-3-(pyridin-3-yl)prop-2-enamideSNNCI
  • NMPRTase Inhibitor APO866SYNCI
  • FK-866CNNCI
  • APO866ABNCI
  • DAPORINADPTFDAV71TF6V9M7
  • K 22.175CNNCI
  • DaporinadPTNCI
DEFINITION
  • A small molecule with potential antineoplastic and antiangiogenic activities. Daporinad binds to and inhibits nicotinamide phosphoribosyltransferase (NMPRTase), inhibiting the biosynthesis of nicotinamide adenine dinucleotide (NAD+) from niacinamide (vitamin B3), which may deplete energy reserves in metabolically active tumor cells and induce tumor cell apoptosis. In addition, this agent may inhibit tumor cell production of vascular endothelial growth factor (VEGF), resulting in the inhibition of tumor angiogenesis. The coenzyme NAD+ plays an essential role in cellular redox reactions, including the redox reaction linking the citric acid cycle and oxidative phosphorylation.NCI
code
  • C67043
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