About: Lutetium Lu-177 Capromab     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Lutetium Lu-177 Capromab
rdfs:subClassOf
Semantic_Type
  • Amino Acid, Peptide, or Protein
  • Indicator, Reagent, or Diagnostic Aid
Preferred_Name
  • Lutetium Lu-177 Capromab
UMLS_CUI
  • C1881486
PDQ_Open_Trial_Search_ID
  • 539702
PDQ_Closed_Trial_Search_ID
  • 539702
Legacy_Concept_Name
  • Lutetium_Lu_177_Monoclonal_Antibody_7E11
FULL_SYN
  • Lutetium Lu-177 CapromabPTNCI
  • 177Lu-meO-DOTA-7E11ABNCI
  • CYT-500CNNCI
  • Lutetium Lu 177-Labeled CapromabSYNCI
DEFINITION
  • A radioimmunoconjugate consisting of capromab linked to lutetium Lu 177 via the bifunctional macrocyclic chelator methoxy-tetraazacyclododecane-tetraacetic acid (MeO-DOTA) with potential antineoplastic activity. Lutetium Lu 177-capromab binds to human prostate specific membrane antigen (PSMA) expressed on tumor cell surfaces via its capromab moiety and, upon internalization, delivers cytotoxic beta radiation directly to PSMA-expressing tumor cells. PSMA is a cell surface glycoprotein abundantly expressed by prostate epithelium and is typically overexpressed by prostate cancer cells.NCI
code
  • C67039
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