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AttributesValues
rdf:type
rdfs:label
  • Palifosfamide
rdfs:subClassOf
Has_Target
Concept_In_Subset
Semantic_Type
  • Organic Chemical
  • Pharmacologic Substance
Preferred_Name
  • Palifosfamide
PubMedID_Primary_Reference
  • 6821629
NSC_Code
  • 297900
UMLS_CUI
  • C0064039
CAS_Registry
  • 31645-39-3
In_Clinical_Trial_For
  • Advanced sarcoma
FDA_UNII_Code
  • 6A4U6NN813
Contributing_Source
  • FDA
PDQ_Open_Trial_Search_ID
  • 538996
PDQ_Closed_Trial_Search_ID
  • 538996
Chemical_Formula
  • C4H11Cl2N2O2P
Legacy_Concept_Name
  • Isophosphoramide_Mustard-Lysine
FULL_SYN
  • PALIFOSFAMIDEPTFDA6A4U6NN813
  • N,N'-Di-(2-chloroethyl)phosphorodiamidic AcidSNNCI
  • PalifosfamidePTNCI
  • ZIO-201CNNCI
  • Isophosphoramide Mustard-LysineSYNCI
  • IPM-LysineABNCI
DEFINITION
  • A synthetic mustard compound with potential antineoplastic activity. An active metabolite of ifosfamide covalently linked to the amino acid lysine for stability, palifosfamide irreversibly alkylates and cross-links DNA through GC base pairs, resulting in irreparable 7-atom inter-strand cross-links; inhibition of DNA replication and cell death follow. Unlike ifosfamide, this agent is not metabolized to acrolein or chloroacetaldehyde, metabolites associated with bladder and CNS toxicities. In addition, because palifosfamide does not require activation by aldehyde dehydrogenase, it may overcome the tumor resistance seen with ifosfamide.NCI
code
  • C66990
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