About: Fidaxomicin

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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	Class
rdfs:label	Fidaxomicin
rdfs:subClassOf	Macrolide Antibiotic nodeID://b719839 nodeID://b719840 nodeID://b719841
Has_Target	DNA-Directed RNA Polymerases
Concept_In_Subset	FDA Established Names and Unique Ingredient Identifier Codes Terminology
Semantic_Type	Pharmacologic Substance
Preferred_Name	Fidaxomicin
UMLS_CUI	C0065023
CAS_Registry	56645-60-4 873857-62-6
Accepted_Therapeutic_Use_For	Clostridial Infection
FDA_UNII_Code	Z5N076G8YQ
Contributing_Source	FDA
ALT_DEFINITION	A substance being studied in the treatment of diarrhea caused by infection with Clostridium difficile (a type of bacteria that can grow without oxygen) in cancer patients. OPT-80 is a type of antibiotic.NCI-GLOSS
PDQ_Open_Trial_Search_ID	530629
PDQ_Closed_Trial_Search_ID	530629
Chemical_Formula	C52H74Cl2O18
Legacy_Concept_Name	Tiacumicin_B
FULL_SYN	FidaxomicinPTNCI Tiacumicin BSYNCI Lipiarmycin A3SYNCI Clostomicin B1SYNCI tiacumicin BPTNCI-GLOSSCDR0000537331 OPT-80PTNCI-GLOSSCDR0000559075 PAR-101PTNCI-GLOSSCDR0000559076 OPT-80CNNCI PAR-101CNNCI DificidBRNCI FIDAXOMICINPTFDAZ5N076G8YQ DifimicinSYNCI
DEFINITION	A narrow-spectrum, 18-membered macrolide antibiotic isolated from the actinomycete Dactylosporangium aurantiacum subsp. hamdenensis with potential antibacterial activity. Although the exact mechanism of action has yet to be fully elucidated, fidaxomicin may bind to and inhibit bacterial DNA-dependent RNA polymerase, thereby inhibiting the initiation of bacterial RNA synthesis. When orally administered, this agent is minimally absorbed into the systemic circulation, acting locally in the gastrointestinal tract. Fidaxomicin appears to be active against pathogenic Gram-positive bacteria, such as clostridia, enterococci, and staphylococci, but does not appear to be active against other beneficial intestinal bacteria.NCI
code	C66979
sameAs	FIDAXOMICIN
http://linked.open...y/mesh/hasConcept	http://linked.opendata.cz/resource/mesh/concept/M0055551
is sameAs of	FIDAXOMICIN FIDAXOMICIN

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