About: Lutetium Lu-177 Girentuximab     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Lutetium Lu-177 Girentuximab
rdfs:subClassOf
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Lutetium Lu-177 Girentuximab
UMLS_CUI
  • C1881485
PDQ_Open_Trial_Search_ID
  • 531051
PDQ_Closed_Trial_Search_ID
  • 531051
Legacy_Concept_Name
  • Lutetium_Lu_177-DOTA-Chimeric_Monoclonal_Antibody_cG250
FULL_SYN
  • Lutetium Lu-177-DOTA-Chimeric Monoclonal Antibody cG250SYNCI
  • Lutetium-177 Labeled cG250SYNCI
  • 177Lu-DOTA-cG250ABNCI
  • Lutetium Lu-177 GirentuximabPTNCI
DEFINITION
  • A radioimmunoconjugate consisting of the chimeric monoclonal antibody cG250 linked to the low energy beta-emitting radioisotope Lutetium 177, via the bifunctional macrocyclic chelating agent tetra-azacyclododecanetetra-acetic acid (DOTA), with potential antineoplastic activity. The antibody moiety of lutetium Lu-177-DOTA-chimeric monoclonal antibody cG250 binds to renal cell carcinoma (RCC) cells expressing the RCC-associated antigen G250; a cytotoxic dose of beta radiation is selectively delivered to G250-expressing RCC cells upon internalization of the radioimmunoconjugate.NCI
code
  • C66978
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