About: Dexrazoxane Hydrochloride     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Dexrazoxane Hydrochloride
rdfs:subClassOf
Has_Free_Acid_Or_Base_Form
Concept_In_Subset
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Dexrazoxane Hydrochloride
UMLS_CUI
  • C0982118
CAS_Registry
  • 149003-01-0
Accepted_Therapeutic_Use_For
  • severe side effects caused by certain types of chemotherapy including extravasation, cardiac side effects by doxorubicin.
FDA_UNII_Code
  • 5346058Q7S
Contributing_Source
  • FDA
ALT_DEFINITION
  • A drug used to treat severe side effects caused by certain anticancer drugs. It is used under the brand name Totect to treat the toxic effects of an anticancer drug that leaks from a vein into surrounding tissue and causes tissue damage. It is also used under the brand name Zinecard to reduce heart damage in women given doxorubicin for breast cancer that has spread. Dexrazoxane hydrochloride is also being studied in the treatment of cancer. It is a type of cardioprotective agent, a type of chemoprotective agent, and a type of topoisomerase inhibitor.NCI-GLOSS
PDQ_Open_Trial_Search_ID
  • 39485
PDQ_Closed_Trial_Search_ID
  • 39485
Chemical_Formula
  • C11H16N4O4.HCl
Legacy_Concept_Name
  • Dexrazoxane_Hydrochloride
CHEBI_ID
  • CHEBI:50224
FULL_SYN
  • dexrazoxane hydrochloridePTNCI-GLOSSCDR0000572255
  • Dexrazoxane HydrochloridePTNCI
  • TotectPTNCI-GLOSSCDR0000572245
  • TotectBRNCI
  • DEXRAZOXANE HYDROCHLORIDEPTFDA5346058Q7S
  • ZinecardPTNCI-GLOSSCDR0000572249
  • ZinecardBRNCI
  • CardioxaneBRNCI
DEFINITION
  • The hydrochloride salt of a bisdioxopiperazine with iron-chelating, chemoprotective, cardioprotective, and antineoplastic activities. After hydrolysis to an active form that is similar to ethylenediaminetetraacetic acid (EDTA), dexrazoxane chelates iron, limiting the formation of free radical-generating anthracycline-iron complexes, which may minimize anthracycline-iron complex-mediated oxidative damage to cardiac and soft tissues. This agent also inhibits the catalytic activity of topoisomerase II, which may result in tumor cell growth inhibition.NCI
code
  • C66945
is Has_Salt_Form of
is sameAs of
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