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AttributesValues
rdf:type
rdfs:label
  • Dapsone Gel
rdfs:subClassOf
Semantic_Type
  • Organic Chemical
  • Pharmacologic Substance
Preferred_Name
  • Dapsone Gel
UMLS_CUI
  • C1639494
PDQ_Open_Trial_Search_ID
  • 494632
PDQ_Closed_Trial_Search_ID
  • 494632
Legacy_Concept_Name
  • Dapsone_Gel
FULL_SYN
  • Dapsone GelPTNCI
  • 5% Dapsone GelSYNCI
  • Dapsone Gel, 5%SYNCI
  • Aczone GelBRNCI
DEFINITION
  • The 5% gel preparation of dapsone, a synthetic derivative of diamino-sulfone with anti-inflammatory and anti-bacterial properties. As a structural analog of p-aminobenzoic acid (PABA), dapsone inhibits dihydropteroate synthase (DHPS), an enzyme important in folate synthesis, resulting in a depletion of the folate pool and a reduction in the amount of thymidylate available for DNA synthesis. Although the exact mechanism through which dapsone exerts its anti-inflammatory activity has yet to be fully elucidated, this agent interferes with the activation and oxidative damage of myeloperoxidase in neutrophils and inhibits the integrin-mediated adherence and chemotaxis of neutrophils. Dapsone's anti-inflammatory activities may contribute to the effects seen upon topical administration.NCI
code
  • C66931
is sameAs of
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