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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Ceftazidime
rdfs:subClassOf
Has_Salt_Form
Concept_In_Subset
Semantic_Type
  • Antibiotic
Preferred_Name
  • Ceftazidime
UMLS_CUI
  • C0007559
CAS_Registry
  • 78439-06-2
FDA_UNII_Code
  • 9M416Z9QNR
Contributing_Source
  • FDA
Chemical_Formula
  • C22H21N6O7S2."H".5H2O
Legacy_Concept_Name
  • Ceftazidime_Base
CHEBI_ID
  • CHEBI:3509
FULL_SYN
  • CeftazidimePTNCI
  • Pyridinium, 1-((7-(((2-amino-4-thiazolyl)((1-carboxy-1-methylethoxy)imino)acetyl)amino)-2-carboxy-8-oxo-5-thia-1-azabicyclo(4.2.0)oct-2-en-3-yl)methyl)-, Hydroxide, Inner Salt, Pentahydrate, (6R-(6alpha,7beta(Z)))-SNNCI
  • Ceftazidime PentahydrateSYNCI
  • CeptazBRNCI
  • FortazBRNCI
  • GR 20263CNNCI
  • PentacefSYNCI
  • LY 139381CNNCI
  • CEFTAZIDIMEPTFDA9M416Z9QNR
DEFINITION
  • A beta-lactam, third-generation cephalosporin antibiotic with bactericidal activity. Ceftazidime binds to and inactivates penicillin-binding proteins (PBP) located on the inner membrane of the bacterial cell wall. PBPs participate in the terminal stages of assembling the bacterial cell wall, and in reshaping the cell wall during cell division. Inactivation of PBPs interferes with the cross-linkage of peptidoglycan chains necessary for bacterial cell wall strength and rigidity. This results in the weakening of the bacterial cell wall and causes cell lysis. Compared to the second and first generation cephalosporins, ceftazidime is more active against gram-negative bacteria and less active against gram-positive bacteria. Ceftazidine also crosses the blood-brain barrier and reaches therapeutic concentrations in the central nervous system (CNS).NCI
code
  • C66868
sameAs
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