About: Zoledronate Disodium     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Zoledronate Disodium
rdfs:subClassOf
Has_Free_Acid_Or_Base_Form
Concept_In_Subset
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Zoledronate Disodium
UMLS_CUI
  • C1883607
CAS_Registry
  • 165800-07-7
FDA_UNII_Code
  • 7D7GS1SA24
Contributing_Source
  • FDA
Chemical_Formula
  • C5H8N2O7P2.2Na.4H2O
Legacy_Concept_Name
  • Zoledronate_Disodium
FULL_SYN
  • ZOLEDRONATE DISODIUMPTFDA7D7GS1SA24
  • Phosphonic Acid, (1-hydroxy-2-(1H-imidazol-1-yl)ethylidene)bis-, Disodium Salt TetrahydrateSNNCI
  • Disodium Dihydrogen (1-hydroxy-2-imidazol-1-ylethylidene)diphosphonate, TetrahydrateSNNCI
  • Zoledronate DisodiumPTNCI
  • CGP 42446ACNNCI
DEFINITION
  • The disodium salt form of zoledronate, a synthetic imidazole, third generation bisphosphonate analog of pyrophosphate with antiresorptive activity. Zoledronate binds to hydroxyapatite crystals in the bone matrix and inhibits farnesyl pyrophosphate (diphosphate) synthase, thereby preventing protein prenylation within the mevalonate pathway. This leads to the loss of downstream metabolites essential for osteoclast function, leading to the induction of apoptosis and eventually, osteoclast-cell death. By preventing osteoclast-mediated bone resorption, zoledronate decreases bone turnover and stabilizes the bone matrix.NCI
code
  • C66703
is Has_Salt_Form of
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