About: Zofenoprilat Arginine     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Zofenoprilat Arginine
rdfs:subClassOf
Concept_In_Subset
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Zofenoprilat Arginine
UMLS_CUI
  • C0646135
CAS_Registry
  • 81872-09-5
FDA_UNII_Code
  • 36F26ZSQ0D
Contributing_Source
  • FDA
Chemical_Formula
  • C15H19NO3S2.C6H14N4O2
Legacy_Concept_Name
  • Zofenoprilat_Arginine
FULL_SYN
  • ZOFENOPRILAT ARGININEPTFDA36F26ZSQ0D
  • SQ 26703CNNCI
  • L-Proline, 1-(3-mercapto-2-methyl-1-oxopropyl)-4-(phenylthio)-, (1(R*),2alpha,4alpha)-, compd. with L-arginine (1:1)SNNCI
  • SQ 26,703CNNCI
  • Zofenoprilat ArgininePTNCI
DEFINITION
  • The arginine salt of zofenoprilat, a sulfhydryl angiotensin-converting enzyme (ACE) inhibitor with antihypertensive activity. Zofenoprilat competitively binds to and inhibits ACE, thereby blocking the conversion of angiotensin I to angiotensin II. This prevents the potent vasoconstrictive actions of angiotensin II and results in vasodilation. Zofenoprilat also decreases angiotensin II-induced aldosterone secretion by the adrenal cortex, which leads to an increase in sodium excretion and subsequently increases water outflow.NCI
code
  • C66700
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