About: Pradefovir Mesylate     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Pradefovir Mesylate
rdfs:subClassOf
Has_Free_Acid_Or_Base_Form
Concept_In_Subset
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Pradefovir Mesylate
UMLS_CUI
  • C1566740
CAS_Registry
  • 625095-61-6
FDA_UNII_Code
  • 0D5204ZSIX
Contributing_Source
  • FDA
Chemical_Formula
  • C17H19ClN5O4P.CH4O3S
Legacy_Concept_Name
  • Pradefovir_Mesylate
FULL_SYN
  • 9-(2-(4-(3-chlorophenyl)-2-oxo-1,3,2-dioxaphosphorinan-2-yl)methoxyethyl)adenineSNNCI
  • 9H-Purin-6-amine, 9-(2-(((2R,4S)-4-(3-chlorophenyl)-2-oxido-1,3,2-dioxaphosphorinan-2-yl)-methoxy)ethyl)-, MonomethanesulfonateSNNCI
  • Remofovir MesylateSYNCI
  • Pradefovir MesylatePTNCI
  • MB-06866QCNNCI
  • PRADEFOVIR MESYLATEPTFDA0D5204ZSIX
  • Hepavir BBRNCI
DEFINITION
  • The mesylate salt form of pradefovir, a cyclodiester antiviral prodrug with specific activity against hepatitis B virus (HBV). Pradefovir is specifically metabolized in the liver by hepatic enzymes, mainly by CYP4503A4, to adefovir. In turn, adefovir is phosphorylated by cellular kinases to its activated form adevofir diphosphate. By competing with the natural substrate dATP, the diphosphate form is incorporated into viral DNA and inhibits RNA-dependent DNA polymerase. This causes DNA chain termination and eventually results in an inhibition of HBV replication.NCI
code
  • C66454
http://linked.open...y/mesh/hasConcept
is Has_Salt_Form of
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