About: Neomycin Sulfate     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Neomycin Sulfate
rdfs:subClassOf
Has_Free_Acid_Or_Base_Form
Concept_In_Subset
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Neomycin Sulfate
UMLS_CUI
  • C0027607
CAS_Registry
  • 1405-10-3
FDA_UNII_Code
  • 057Y626693
Contributing_Source
  • FDA
Legacy_Concept_Name
  • Neomycin_Sulfate
CHEBI_ID
  • CHEBI:31635
FULL_SYN
  • NEOMYCIN SULFATEPTFDA057Y626693
  • Neomycin SulfatePTNCI
DEFINITION
  • The sulfate salt form of neomycin, a broad spectrum aminoglycoside antibiotic derived from Streptomyces fradiae with antibacterial activity. Neomycin is an antibiotic complex consisting of 3 components: the two isomeric components B and C are the active components, and neomycin A is the minor component. Neomycin irreversibly binds to the 16S rRNA and S12 protein of the bacterial 30S ribosomal subunit. As a result, this agent interferes with the assembly of initiation complex between mRNA and the bacterial ribosome, thereby inhibiting the initiation of protein synthesis. In addition, neomycin induces misreading of the mRNA template and causes translational frameshift, thereby results in premature termination. This eventually leads to bacterial cell death.NCI
code
  • C66227
sameAs
http://linked.open...y/mesh/hasConcept
is Has_Salt_Form of
is sameAs of
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