About: Mangafodipir Trisodium     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Mangafodipir Trisodium
rdfs:subClassOf
Concept_In_Subset
Semantic_Type
  • Organic Chemical
  • Pharmacologic Substance
  • Indicator, Reagent, or Diagnostic Aid
Preferred_Name
  • Mangafodipir Trisodium
UMLS_CUI
  • C0067297
CAS_Registry
  • 140678-14-4
FDA_UNII_Code
  • 129FW80TG4
Contributing_Source
  • FDA
PDQ_Open_Trial_Search_ID
  • 596487
PDQ_Closed_Trial_Search_ID
  • 596487
Chemical_Formula
  • C22H27N4O14P2.Mn.3Na
Legacy_Concept_Name
  • Mangafodipir_Trisodium
FULL_SYN
  • Mangafodipir TrisodiumPTNCI
  • MANGAFODIPIR TRISODIUMPTFDA129FW80TG4
DEFINITION
  • The trisodium salt of mangafodipir with potential antioxidant and chemoprotective activities. Consisting of manganese (II) ions chelated to fodipir (dipyridoxyl diphosphate or DPDP), mangafodipir scavenges oxygen free radicals such as superoxide anion, hydrogen peroxide, and hydroxyl radical, potentially preventing oxygen free radical damage to macromolecules such as DNA and minimizing oxygen free radical-related chemotoxicity in normal tissues. However, this agent may potentiate the chemotherapy-induced generation of oxygen free radicals in tumor cells, resulting in the potentiation of chemotherapy-induced cytotoxicity; tumor cells, with higher levels of reactive oxygen species than normal cells, possess a lower threshold for oxygen free radical-mediated cytotoxicity. Mangafodipir is traditionally used as an imaging agent in magnetic resonance imaging (MRI).NCI
code
  • C66053
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