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AttributesValues
rdf:type
rdfs:label
  • Levocetirizine
rdfs:subClassOf
Has_Salt_Form
Concept_In_Subset
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Levocetirizine
UMLS_CUI
  • C1174893
CAS_Registry
  • 130018-77-8
FDA_UNII_Code
  • 6U5EA9RT2O
Contributing_Source
  • FDA
Chemical_Formula
  • C21H25ClN2O3
Legacy_Concept_Name
  • Levocetirizine
FULL_SYN
  • LEVOCETIRIZINEPTFDA6U5EA9RT2O
  • LevocetirizinePTNCI
DEFINITION
  • A third generation, non-sedating, selective histamine H1 receptor antagonist, with antihistamine, anti-inflammatory and potential anti-angiogenic activities. Levocetirizine competes with endogenous histamine for binding at peripheral H1-receptor sites on the effector cell surface. This prevents the negative symptoms associated with histamine release and an allergic reaction. In addition, as histamine plays an important role in angiogenesis during an allergic inflammatory reaction, blocking the action of histamine may modulate the expression of proangiogenic factors and thus may prevent angiogenesis. As a third-generation histamine H1 receptor antagonist, levocetirizine has fewer side effects than most second-generation antihistamines.NCI
code
  • C66008
sameAs
http://linked.open...y/mesh/hasConcept
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