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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Forasartan
rdfs:subClassOf
Concept_In_Subset
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Forasartan
UMLS_CUI
  • C0250070
CAS_Registry
  • 145216-43-9
FDA_UNII_Code
  • 065F7WPT0B
Contributing_Source
  • FDA
Chemical_Formula
  • C23H28N8
Legacy_Concept_Name
  • Forasartan
FULL_SYN
  • 5-((3,5-dibutyl-1H-1,2,4-triazol-1-yl)methyl)-2-(2-(1H-tetrazol-5-yl)phenyl)pyridineSNNCI
  • SC 52458CNNCI
  • FORASARTANPTFDA065F7WPT0B
  • ForasartanPTNCI
DEFINITION
  • A nonpeptide angiotensin II receptor antagonist with antihypertensive activity. Forasartan selectively competes with angiotensin II for the binding of the angiotensin II (AT1) receptor subtype 1 in vascular smooth muscle, thereby blocking angiotensin II-mediated vasoconstriction resulting in vascular dilatation. In addition, the antagonistic effect on AT1 in the adrenal gland, prevents angiotensin II-induced stimulation of aldosterone synthesis and secretion by the adrenal cortex. This blocks the effects of aldosterone leading to an increase in sodium excretion and water and eventually a reduction in plasma volume and blood pressure.NCI
code
  • C65749
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