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AttributesValues
rdf:type
rdfs:label
  • Febuxostat
rdfs:subClassOf
Concept_In_Subset
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Febuxostat
PubMedID_Primary_Reference
  • 16339094
UMLS_CUI
  • C2683462
CAS_Registry
  • 144060-53-7
FDA_UNII_Code
  • 101V0R1N2E
Contributing_Source
  • FDA
PDQ_Open_Trial_Search_ID
  • 743107
PDQ_Closed_Trial_Search_ID
  • 743107
Chemical_Formula
  • C16H16N2O3S
Legacy_Concept_Name
  • Febuxostat
CHEBI_ID
  • CHEBI:45943
FULL_SYN
  • 2-(3-Cyano-4-(2-methylpropoxy)phenyl)-4-methylthiazole-5-carboxylic AcidSNNCI
  • TMX 67CNNCI
  • UloricBRNCI
  • FEBUXOSTATPTFDA101V0R1N2E
  • AdenuricFBNCI
  • FebuxostatPTNCI
DEFINITION
  • An orally available, non-purine inhibitor of xanthine oxidase with uric acid lowering activity. Upon oral administration, febuxostat selectively and noncompetitively inhibits the activity of xanthine oxidase, an enzyme that converts oxypurines, including hypoxanthine and xanthine, into uric acid. By inhibiting xanthine oxidase, uric acid production is reduced and serum uric acid levels are lowered. Febuxostat may provide protection against acute renal failure caused by the excessive release of uric acid that occurs upon massive tumor cell lysis resulting from the treatment of some malignancies.NCI
code
  • C65629
sameAs
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