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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Eszopiclone
rdfs:subClassOf
Concept_In_Subset
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Eszopiclone
UMLS_CUI
  • C1436328
CAS_Registry
  • 138729-47-2
Accepted_Therapeutic_Use_For
  • Insomnia
FDA_UNII_Code
  • UZX80K71OE
Contributing_Source
  • FDA
PDQ_Open_Trial_Search_ID
  • 538994
PDQ_Closed_Trial_Search_ID
  • 538994
Chemical_Formula
  • C17H17ClN6O3
Legacy_Concept_Name
  • Eszopiclone
CHEBI_ID
  • CHEBI:53760
FULL_SYN
  • EszopiclonePTNCI
  • (S)-ZopicloneSYNCI
  • (+)-(5S)-6-(5-Chloropyridin-2-yl)-7-oxo-6,7-dihydro-5H-pyrrolo(3,4-b)pyrazin-5-yl 4-methylpiperazine-1-carboxylateSNNCI
  • SEP-190CNNCI
  • LunestaBRNCI
  • ESZOPICLONEPTFDAUZX80K71OE
DEFINITION
  • A nonbenzodiazepine, cyclopyrrolone and active stereoisomer of zopiclone with hypnotic and sedative activity and without significant anxiolytic activity. Although the exact mechanism of action remains to be fully elucidated, eszopiclone is able to bind to and activate the omega-1 subtype of the alpha subunit of the gamma-aminobutyric acid-benzodiazepine GABA receptor complex (GABA-A), a chloride ionophore complex in the central nervous system (CNS). This leads to the opening of chloride channels, causing hyperpolarization, inhibition of neuronal firing, and enhancement of the inhibitory effect of GABA. This eventually leads to a hypnotic effect and allows for an induction of sleep.NCI
code
  • C65545
sameAs
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