About: Duloxetine Hydrochloride     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Duloxetine Hydrochloride
rdfs:subClassOf
Has_Free_Acid_Or_Base_Form
Concept_In_Subset
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Duloxetine Hydrochloride
UMLS_CUI
  • C1505021
CAS_Registry
  • 136434-34-9
FDA_UNII_Code
  • 9044SC542W
Contributing_Source
  • FDA
ALT_DEFINITION
  • A drug used to treat depression and peripheral neuropathy (pain, numbness, tingling, burning, or weakness in the hands or feet) that can occur with diabetes. It is also being studied in the treatment of peripheral neuropathy caused by certain anticancer drugs. Duloxetine hydrochloride increases the amount of certain chemicals in the brain that help relieve depression and pain. It is a type of serotonin and norepinephrine reuptake inhibitor.NCI-GLOSS
PDQ_Open_Trial_Search_ID
  • 553629
PDQ_Closed_Trial_Search_ID
  • 553629
Chemical_Formula
  • C18H19NOS.HCl
Legacy_Concept_Name
  • Duloxetine_Hydrochloride
CHEBI_ID
  • CHEBI:31526
FULL_SYN
  • duloxetine hydrochloridePTNCI-GLOSSCDR0000589399
  • Duloxetine HydrochloridePTNCI
  • DULOXETINE HYDROCHLORIDEPTFDA9044SC542W
  • cymbaltaPTNCI-GLOSSCDR0000589398
  • CymbaltaBRNCI
DEFINITION
  • The hydrochloride salt of duloxetine, a fluoxetine derivative belonging to the class of selective serotonin (5-HT) and norepinephrine (NE) reuptake inhibitors (SSNRIs) and exhibiting antidepressant activity. Duloxetine selectively prevents the reuptake of 5-HT and NE via transporter complexes on the pre-synaptic membrane, thereby increasing the level of these neurotransmitters within the synaptic cleft. As a result, this agent potentiates serotonergic and noradrenergic activities in the central nervous system, and alleviates depression and neuropathy sensations, such as pain and tingling. Furthermore, duloxetine does not show significant affinity for dopaminergic, adrenergic, cholinergic, histaminergic, opioid, glutamate, and gamma-aminobutyric acid (GABA) receptors.NCI
code
  • C65496
sameAs
http://linked.open...y/mesh/hasConcept
is Has_Salt_Form of
is sameAs of
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