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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Doripenem
rdfs:subClassOf
Concept_In_Subset
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Doripenem
UMLS_CUI
  • C0389169
CAS_Registry
  • 148016-81-3
Accepted_Therapeutic_Use_For
  • Intraabdominal Infection, Urinary Tract Infection
FDA_UNII_Code
  • BHV525JOBH
Contributing_Source
  • FDA
Chemical_Formula
  • C15H24N4O6S2
Legacy_Concept_Name
  • Doripenem
FULL_SYN
  • S-4661CNNCI
  • DORIPENEMPTFDABHV525JOBH
  • FInibaxFBNCI
  • DoribaxBRNCI
  • DoripenemPTNCI
DEFINITION
  • A broad-spectrum, carbapenem antibiotic with bactericidal and beta-lactamase resistant activities. Doripenem binds to penicillin binding proteins (PBPs) located on the bacterial cell wall, particularly PBPs 2 and 3, thereby inhibiting the final transpeptidation step in the synthesis of peptidoglycan, an essential component of the bacterial cell wall. Inhibition results in a weakening and eventually lysis of the bacterial cell wall. This agent is two- to 16-fold more potent than imipenem and comparable to ertapenem and meropenem.NCI
code
  • C65470
sameAs
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