About: Cerivastatin     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Cerivastatin
rdfs:subClassOf
Has_Salt_Form
Concept_In_Subset
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Cerivastatin
UMLS_CUI
  • C0528023
CAS_Registry
  • 145599-86-6
FDA_UNII_Code
  • AM91H2KS67
Contributing_Source
  • FDA
Chemical_Formula
  • C26H34FNO5
Legacy_Concept_Name
  • Cerivastatin
CHEBI_ID
  • CHEBI:3558
FULL_SYN
  • CERIVASTATINPTFDAAM91H2KS67
  • CerivastatinPTNCI
DEFINITION
  • A synthetic lipid-lowering agent. Cerivastatin competitively inhibits hepatic hydroxymethyl-glutaryl coenzyme A (HMG-CoA) reductase, the enzyme which catalyzes the conversion of HMG-CoA to mevalonate, a key step in cholesterol synthesis. This agent lowers plasma cholesterol and lipoprotein levels, and modulates immune responses by suppressing major histocompatibility complex II on interferon gamma-stimulated, antigen-presenting cells such as human vascular endothelial cells. Muscle toxicity (myopathy and rhabdomyolysis) precludes the clinical use of this agent.NCI
code
  • C65308
sameAs
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