About: Alefacept

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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	Class
rdfs:label	Alefacept
rdfs:subClassOf	IMMUNE SUPPRESSANTS nodeID://b644812 nodeID://b644813 nodeID://b644814 nodeID://b644815
Has_Target	Antigens, CD2
Concept_In_Subset	FDA Established Names and Unique Ingredient Identifier Codes Terminology
Semantic_Type	Pharmacologic Substance
Preferred_Name	Alefacept
UMLS_CUI	C0962603
CAS_Registry	222535-22-0
In_Clinical_Trial_For	Graft versus host disease; Cutaneous T-cell lymphoma; peripheral T-cell non-Hodgkin's lymphoma
FDA_UNII_Code	ELK3V90G6C
Contributing_Source	FDA
ALT_DEFINITION	A drug that is used to treat certain skin conditions and is being studied in the treatment of cutaneous (skin-related) T-cell cancer and T-cell non-Hodgkin lymphoma. Alefacept is made by combining part of an antibody with a protein that blocks the growth some types of T cells. It is a type of fusion protein and a type of immunosuppressant.NCI-GLOSS
PDQ_Open_Trial_Search_ID	531798
PDQ_Closed_Trial_Search_ID	531798
Legacy_Concept_Name	Alefacept
FULL_SYN	ALEFACEPTPTFDAELK3V90G6C AmevivePTNCI-GLOSSCDR0000572133 LFA3TIPSYNCI AmeviveBRNCI AlefaceptPTNCI alefaceptPTNCI-GLOSSCDR0000538645
DEFINITION	A recombinant dimeric fusion protein consisting of the extracellular CD2-binding domain of the human leukocyte function-associated antigen 3 (LFA-3; CD58) linked to the Fc portion of human immunoglobulin G1 (IgG1) with potential immunosuppressive activity. Alefacept binds to the CD2 receptor expressed on the majority of T lymphocytes, blocking the binding of endogenous LFA-3, located on antigen-presenting cells (APCs), to the CD2 receptor; the activation and proliferation of T lymphocytes in response to LFA-3 binding is thus inhibited. In addition, binding of the IgG1 moiety of this agent to the Fc gamma receptor on the surface of natural killer (NK)cells may bridge NK cells and target T lymphocytes, initiating NK cell-mediated apoptosis of T lymphocytes.NCI
code	C65220
sameAs	ALEFACEPT
http://linked.open...y/mesh/hasConcept	http://linked.opendata.cz/resource/mesh/concept/M0374901
is sameAs of	ALEFACEPT ALEFACEPT

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