About: Adalimumab

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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	Class
rdfs:label	Adalimumab
rdfs:subClassOf	Antibodies, Monoclonal Immunomodulating Agent
Concept_In_Subset	FDA Established Names and Unique Ingredient Identifier Codes Terminology
Semantic_Type	Pharmacologic Substance
Preferred_Name	Adalimumab
UMLS_CUI	C1122087
CAS_Registry	331731-18-1
Accepted_Therapeutic_Use_For	Rheumatoid Arthritis, Crohn's Disease, Ankylosing Spondylitis, Psoriatic Arthritis
FDA_UNII_Code	FYS6T7F842
Contributing_Source	FDA
Legacy_Concept_Name	Adalimumab
FULL_SYN	D2E7CNNCI HumiraBRNCI ADALIMUMABPTFDAFYS6T7F842 LU200134CNNCI Immunoglobulin G1, anti-(human tumor necrosis factor) (human monoclonal D2E7 heavy chain), disulfide with human monoclonal D2E7 light chain, dimerSYNCI AdalimumabPTNCI
DEFINITION	A recombinant, human IgG1 monoclonal antibody directed against tumor necrosis factor-alpha (TNF-alpha), with immunomodulating activity. Upon administration, adalimumab binds to TNF-alpha, thereby preventing its binding to the p55 and p75 TNF cell surface receptors and inhibiting TNF-mediated immune responses. TNF-alpha, a pro-inflammatory cytokine, is upregulated in various autoimmune diseases.NCI
code	C65216
sameAs	ADALIMUMAB
http://linked.open...y/mesh/hasConcept	http://linked.opendata.cz/resource/mesh/concept/M0422769
is sameAs of	ADALIMUMAB ADALIMUMAB

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