About: Acolbifene Hydrochloride     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Acolbifene Hydrochloride
rdfs:subClassOf
Has_Free_Acid_Or_Base_Form
Concept_In_Subset
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Acolbifene Hydrochloride
UMLS_CUI
  • C1879543
CAS_Registry
  • 252555-01-4
FDA_UNII_Code
  • KXC7811DBY
Contributing_Source
  • FDA
ALT_DEFINITION
  • A substance being studied in the prevention of breast cancer in women at high risk of breast cancer. Acolbifene hydrochloride binds to estrogen receptors in the body and blocks the effects of estrogen in the breast. It is a type of selective estrogen receptor modulator (SERM).NCI-GLOSS
PDQ_Open_Trial_Search_ID
  • 636416
PDQ_Closed_Trial_Search_ID
  • 636416
Chemical_Formula
  • C29H31NO4.ClH
Legacy_Concept_Name
  • Acolbifene_Hydrochloride
FULL_SYN
  • acolbifene hydrochloridePTNCI-GLOSSCDR0000644298
  • Acolbifene HydrochloridePTNCI
  • ACOLBIFENE HYDROCHLORIDEPTFDAKXC7811DBY
DEFINITION
  • The hydrochloride salt form of acolbifene, a fourth-generation estrogen receptor modulator (SERM) with potential lipid lowering and antineoplastic activity. Acolbifene specifically binds to estrogen receptors in responsive tissue, including liver, bone, breast, and endometrium. The resulting ligand-receptor complex is translocated to the nucleus where, depending on the tissue type, it promotes or suppresses the transcription of estrogen-regulated genes, thereby exerting its agonistic or antagonistic effects. Acolbifene acts as an estrogen antagonist in uterine and breast tissue, thereby blocking the effects of estrogen in these tissues. This may inhibit tumor cell proliferation in ER-positive tumor cells. This agent functions as an estrogen agonist in lipid metabolism, thereby decreasing total and LDL cholesterol levels. In bone, it decreases bone resorption and bone turnover and increases bone mineral density.NCI
code
  • C65213
is Has_Salt_Form of
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