About: Metoclopramide Hydrochloride     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Metoclopramide Hydrochloride
rdfs:subClassOf
Has_Free_Acid_Or_Base_Form
Concept_In_Subset
Semantic_Type
  • Organic Chemical
  • Pharmacologic Substance
Preferred_Name
  • Metoclopramide Hydrochloride
NSC_Code
  • 354467
UMLS_CUI
  • C0887128
CAS_Registry
  • 7232-21-5
FDA_UNII_Code
  • W1792A2RVD
Contributing_Source
  • FDA
ALT_DEFINITION
  • A drug that increases the motility (movements and contractions) of the stomach and upper intestine. It is used to treat certain stomach problems and nausea and vomiting caused by chemotherapy. It is a type of antiemetic and a type of motility agent.NCI-GLOSS
PDQ_Open_Trial_Search_ID
  • 39502
PDQ_Closed_Trial_Search_ID
  • 39502
Chemical_Formula
  • C14H22ClN3O2.HCl.H2O
Legacy_Concept_Name
  • Metoclopramide
CHEBI_ID
  • CHEBI:6899
FULL_SYN
  • METOCLOPRAMIDE HYDROCHLORIDEPTFDAW1792A2RVD
  • ReglanPTNCI-GLOSSCDR0000485223
  • ReglanBRNCI
  • Metoclopramide HydrochloridePTNCI
DEFINITION
  • The hydrochloride salt of the substituted benzamide metoclopramide, a para-aminobenzoic acid (PABA) derivative that is structurally related to procainamide, with gastroprokinetic and antiemetic activities. Metoclopramide binds to dopamine 2 (D2) receptors in the peripheral nervous system (PNS), antagonizing dopamine-mediated relaxation of gastrointestinal smooth muscle and promoting gastroprokinesis; the pyloric sphincter and the duodenal bulb are relaxed, peristalsis of the duodenum and jejunum increase, and gastric emptying and intestinal transit accelerate. This agent may also increase the resting tone of the lower esophagus sphincter (LES), preventing acid reflux. In the central nervous system (CNS), metoclopramide antagonizes D2 dopamine receptors in the chemoreceptive trigger zone (CTZ) of the medulla, thereby preventing nausea and vomiting.NCI
code
  • C649
sameAs
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