About: DTA-H19 Plasmid     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • DTA-H19 Plasmid
rdfs:subClassOf
Has_Target
Semantic_Type
  • Organic Chemical
  • Pharmacologic Substance
  • Gene or Genome
Preferred_Name
  • DTA-H19 Plasmid
UMLS_CUI
  • C1831996
PDQ_Open_Trial_Search_ID
  • 525721
PDQ_Closed_Trial_Search_ID
  • 525721
Legacy_Concept_Name
  • DTA-H19_Plasmid
FULL_SYN
  • DTA-H19 PlasmidPTNCI
  • DTA-H19SYNCI
  • Diphtheria Toxin A-H19 PlasmidSYNCI
DEFINITION
  • A plasmid DNA encoding the A chain of the diphtheria toxin (DT-A) driven by the transcriptional regulatory sequences of human H19, with potential antineoplastic activity. Because the expression of DT-A is under the control of H19 promotor elements, DT-A is selectively expressed in tumor cells capable of turning on H-19. DT-A catalyzes ADP-ribosylation of translation elongation factor 2 (EF-2), resulting in the inhibition of protein synthesis and apoptosis. In addition, DT-A protein released from lysed cells cannot enter and kill neighboring cells because of the absence of the DT-B chain, further enhancing the selective cytotoxicity of this agent. Human H19 is a paternally-imprinted, oncofetal gene encoding an RNA product; it acts as a riboregulator in gene expression and is found at substantial levels in different human tumor cell types while its expression in normal adult tissue is limited.NCI
code
  • C64845
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