About: DACH Polymer Platinate AP5346     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • DACH Polymer Platinate AP5346
rdfs:subClassOf
Has_Target
Semantic_Type
  • Organic Chemical
  • Pharmacologic Substance
Preferred_Name
  • DACH Polymer Platinate AP5346
UMLS_CUI
  • C1723251
ALT_DEFINITION
  • A substance being studied in the treatment of head and neck cancer. It may kill cancer cells by carrying an anticancer drug into the tumor. It is a type of platinum compound.NCI-GLOSS
PDQ_Open_Trial_Search_ID
  • 526175
PDQ_Closed_Trial_Search_ID
  • 526175
Legacy_Concept_Name
  • DACH_Polymer_Platinate_AP5346
FULL_SYN
  • AP5346PTNCI-GLOSSCDR0000533419
  • AP5346CNNCI
  • DACH Polymer Platinate AP5346PTNCI
DEFINITION
  • A low molecular weight polymer-conjugated platinum complex with potential antineoplastic activity. This polymer drug delivery system consists of cytotoxic diaminocyclohexane (DACH)-platinum (Pt) coupled to a water-soluble biocompatible hydroxypropylmethacrylamide (HPMA) copolymer via a pH sensitive linker. Due to decreased pH at the tumor site, the linker is cleaved and the chelated active moiety DACH-Pt is released in tumor cells. DACH-Pt alkylates macromolecules and causes both inter- and intra-strand platinum-DNA crosslinks, which impede DNA replication and transcription, thereby resulting in cell-cycle independent cytotoxicity. The HPMA-based drug delivery system enhances the concentration of DACH-Pt at the tumor site and prolongs the half life of the agent, thereby increasing exposure and efficacy at the target tumor sites while minimizing side effects in normal tissues.NCI
code
  • C64784
http://linked.open...y/mesh/hasConcept
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