About: E2F1 Pathway Activator ARQ 171     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • E2F1 Pathway Activator ARQ 171
rdfs:subClassOf
Has_Target
Semantic_Type
  • Organic Chemical
  • Pharmacologic Substance
Preferred_Name
  • E2F1 Pathway Activator ARQ 171
UMLS_CUI
  • C1832018
PDQ_Open_Trial_Search_ID
  • 529342
PDQ_Closed_Trial_Search_ID
  • 529342
Legacy_Concept_Name
  • ARQ_171
FULL_SYN
  • ARQ 171CNNCI
  • E2F1 Pathway Activator ARQ 171PTNCI
DEFINITION
  • A second-generation E2F1 pathway activator with potential antineoplastic activity. ARQ 171 induces the expression of E2F transcription factor 1, thereby activating the E2F1-mediated checkpoint process. E2F1, down-regulated in cancer cells, regulates expression of genes involved in the cell cycle progression from G1 into S phase. The G1/S checkpoint process selectively induces cell cycle arrest in cancer cells with irreparable DNA damages and triggers subsequent apoptosis, while allowing cell division to proceed in cells without or with minor reparable DNA damage. As a result, this agent exerts anti-tumor activity through checkpoint activation independent of p53 mediated tumor suppression.NCI
code
  • C64767
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